Brett Kavanaugh denies Christine Blasey Ford sex assault claim.
The man nominated for a vacant post on the US Supreme Court by Donald Trump emphatically denied allegations of sexual assault on Thursday.
Brett Kavanaugh told the Senate Judiciary Committee his confirmation process had become a "disgrace".
He accused Democratic senators of destroying his family and his good name for political reasons.
Earlier, Christine Blasey Ford said an assault by Mr Kavanaugh 36 years ago had "drastically" affected her life.
Dr Ford told the committee that the alleged event had left her "afraid and ashamed".
President Donald Trump has now said the Senate "must vote" on Mr Kavanaugh's confirmation to the Supreme Court.
The nine-member Supreme Court plays a vital role in US political life, as it has the final say on US law.
This includes highly contentious social issues, such as abortion, and challenges to government policy.
Taking a combative approach but occasionally becoming emotional, Mr Kavanaugh, 53 - a federal judge - went on the offensive following Dr Ford's testimony.
"This confirmation process has become a national disgrace," he told the committee.
"The constitution gives the Senate an important role in the confirmation process, but you have replaced advice and consent with search and destroy.
"Since my nomination in July there has been a frenzy on the left to come up with something, anything to block my confirmation."
He insisted he would not be "intimidated" into withdrawing from the process.
"You may defeat me in the final vote but you'll never get me to quit. Never."
Mr Kavanaugh said he did not doubt that Dr Ford had been assaulted, but insisted: "I've never sexually assaulted Dr Ford - or anyone."
He admitted he had drunk beer while at high school and under-age, but said he had never got so drunk as to forget events.
He added that his calendars for 1982 - which he had kept - showed he had not attended a party at the location Dr Ford had described.
Under hostile questioning from Democratic senators, he repeatedly insisted he was innocent and said an FBI investigation -suggested by Dr Ford to establish the truth - would be useless as it would not reach conclusions.