Bob Saget, the actor and comedian most famous for his role in the much-loved 80s sitcom Full House, has died at the age of 65.

The Orange County sheriff’s office confirmed Saget’s death on Twitter on Monday, saying he had been found unresponsive in his hotel room at the Ritz-Carlton in Orlando, Florida on Sunday. The sheriff’s office confirmed that no cause of death had been determined, saying in a statement there were no signs of foul play or drug use.

Saget was partway through a standup tour and had performed a show in Jacksonville on Saturday night.

Comedians and actors rushed to pay tribute on Monday. Jon Stewart remembered him as “just the nicest and funniest”, while podcaster Marc Maron tweeted: “Truly one of the nicest guys and so funny. Very sad.” Comedian Drew Carey wrote: “Well this one hurts. I loved Bob Saget. He gave me so much encouragement when I first started out. He was a real friend to me too. Not just a mentor. I always looked up to him. He was SO damn funny and so kind.” Comedian Kathy Griffin wrote: “You couldn’t find a nicer or sharper wit than Bob Saget. Shocked and devastated.”

In 1987, Saget was cast as patriarch Danny Tanner on ABC’s “Full House,” where he played the father of D.J. (Candace Cameron), Stephanie (Jodie Sweetin) and Michelle Tanner (Mary-Kate and Ashley Olsen). In the show, he raises his daughters as a single dad after the death of his wife, and he was joined by his brother-in-law Jesse Katsopolis (John Stamos) and his best friend Joey Gladstone (Dave Coulier) to run their adorably dysfunctional sitcom family. The show ran for eight seasons and 192 episodes from 1987 to 1994, reaching more than 17 million viewers during its peak in Season 5. From Season 3 onwards, “Full House” was in the Nielsen Top 30 TV shows.