The 90-minute debate will begin at 9 p.m. (0100 GMT on Tuesday) at Hofstra University on New York's Long Island. It is the first of three planned presidential debates
Democrat Hillary Clinton and Republican Donald Trump will face off for the first time on Monday in a presidential debate that could rank as one of the most watched and highly anticipated political showdowns in U.S. history.
The surprisingly tight race for the White House and the unpredictable clash in styles between well-known but polarizing foes has generated wide interest in the potentially pivotal encounter, which comes six weeks before the Nov. 8 election.
The size of the audience is expected to challenge the presidential debate record of 80 million who watched the 1980 encounter between Democratic President Jimmy Carter and Republican Ronald Reagan.
The 90-minute debate will begin at 9 p.m. (0100 GMT on Tuesday) at Hofstra University on New York's Long Island. It is the first of three planned presidential debates.
Both Trump and Clinton, who polls show are the least liked White House candidates in modern history, hope to use the debate to erase some of those lingering voter doubts and address campaign-trail weaknesses.
The volatile Trump, a businessman and former reality television star, will get a chance to show a depth and steadiness worthy of a credible commander in chief, while the cautious Clinton will be able to try to connect directly with voters who do not trust her, strategists said.
But Trump, a political newcomer who has often shown more affinity for putdowns than policy, could benefit from lower expectations from voters.
"There is no question it's a lower bar for Trump. He doesn't have to be brilliant, he just can't be too bombastic," said Dan Schnur, a former Republican strategist who is now a political scientist at the University of Southern California.
The stakes are enormous. The debate comes as polls show Clinton's once sizable lead over Trump has evaporated amid more questions about her family foundation and her use of a private email server while secretary of state.
A Reuters/Ipsos poll released on Monday showed half of America's likely voters would rely on the debates to help them make their choice. More than half, 61 percent, were hoping for a civil debate and were not interested in the bitterness shown on the campaign trail.